Clinical evaluation of tumor characteristics predisposing serum thyroglobulin to be undetectable in patients with differentiated thyroid cancer

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Pathological evaluation of differentiated thyroid cancer in patients with positive serum thyroglobulin and negative iodine scan.

OBJECTIVE There is no investigation that emphasizes the pathology of DTC (differentiated thyroid cancer) patients with positive Tg and negative iodine scan. The present study was performed to assess the pathology of these patients. MATERIALS AND METHODS In this retrospective study, the records of 500 patients with differentiated thyroid cancer between June 2005 and November 2011 were assessed...

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How to manage patients with undetectable thyroglobulin but thyroid residue after radioiodine ablative therapy in differentiated thyroid carcinoma, retreatment or observation?

Introduction:Differentiated thyroid carcinoma (DTC) follow-up after thyroidectomy and radioiodine-ablation is performed mainly by thyroglobulin (Tg), diagnostic iodine-131 whole body scan (DxWBS) and sonography. Some patients with undetectable Tg have thyroid-bed uptake after ablation in whom decision making regarding the need for retreatment is still controversial. Me...

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Preoperative determination of serum thyroglobulin to identify patients with differentiated thyroid cancer who may present recurrence without increased thyroglobulin.

Thyroglobulin is considered a reliable marker of recurrent disease in patients with well-differentiated thyroid carcinoma. However, some patients present recurrence with no increase in serum thyroglobulin. In the attempt to identify patients who might present recurrence with no such sign of the disease, thyroglobulin levels have been determined pre-operatively in 185 consecutive patients schedu...

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[Serum thyroglobulin levels in patients with thyroid tumor].

Serum thyroglobulin (Tg) levels were measured in 15 normal volunteers, 69 patients with differentiated thyroid carcinoma, 22 with adenoma, 45 with adenomatous goiter, 5 with functioning adenoma and 24 with Graves' disease, utilizing a double antibody radioimmunoassay technique. Serum Tg levels in the normal volunteers were found to be less than 30 ng/ml as determined from their mean value, i.e....

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ژورنال

عنوان ژورنال: Cancer

سال: 1988

ISSN: 0008-543X,1097-0142

DOI: 10.1002/1097-0142(19880301)61:5<976::aid-cncr2820610520>3.0.co;2-u